In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.
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Links
- The Sinclair Lab website
- Nicotinamide riboside is well-tolerated in humans
- Nicotinamide riboside is a sirtuin-activator
- Mice treated with nicotinamide riboside are longer-lived
- Nicotinamide riboside protects mice against obesity
- An inflammatory signature is attenuated by nicotinamide riboside
- Nicotinamide riboside, pterostilbene, and ALS
- Nicotinamide mononucleotide combats diabetes in mice
- Aging is slowed by nicotinamide mononucleotide
- Nicotinamide mononucleotide in prediabetic women
- NAD and cancer in mice
- Resveratrol protects mice against a high-calorie diet
- Resveratrol in patients with type 2 diabetes
- Supplementing resveratrol in metabolic syndrome patients
- Fisetin enhances longevity in mice
- Quercetin and fatty liver disease
- Dasatinib and quercetin decrease senescent cell burden
- Mice fed rapamycin late in life live longer
- Spermidine induces life extension and cardioprotection in mice
- Spermidine and older subjects with cognitive decline
- Healthspan and lifespan in mice are improved by metformin
- Metformin, age-related diseases, and mortality
- Targeting aging with metformin (TAME) trial
- Treating mice with berberine extends lifespan
- Lifespan in fruit flies is prolonged by berberine
- Berberine and metabolic disorders
Timestamps
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support
