In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.
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- The cerebellum in the brain ages slowly
- Neuronal cells have a lower epigenetic age
- Sirt1 regulates aging in mice
- Mediterranean diet and brain health
- Mediterranean diet and dementia risk
- Aerobic exercise improves executive functioning
- Exercise and mouse models of neurodegenerative disease
- Strength exercises elevate the expression of BDNF
- Metformin enhances cognitive ability in fish
- Alzheimer’s disease and metformin
- Metformin use correlates with a reduced risk of dementia
- NAD boosting and Alzheimer’s disease
- ALS, nicotinamide riboside, and pterostilbene
- Vascular aging and NAD in mice
- In mice, overexpressing Sirt1 in the brain extends lifespan
- Sirt1 ameliorates amyotrophic lateral sclerosis in mice
- Sirt1 protects against Alzheimer’s disease in mice
- Sirt1 and neuroprotection in a mouse model of Huntington’s disease
- Sleep loss reduces lifespan in flies
- A single night of sleep deprivation increases amyloid-beta
- All-cause mortality correlates with sleep duration
Timestamps
00:00:00 Introducing Episode Seven: Aging of the Brain
00:04:39 Thanking the Sponsors
00:07:38 Ex-differentiation as a Driver of Aging
00:09:22 The Brain Ages Slowly
00:14:17 Cognitive Function and Plasticity
00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins
00:23:26 Plant-based Diets and B-vitamins
00:28:32 Homocysteine, Plaque, and Vasculature
00:32:35 Fatty Acids
00:35:48 Physical Activity
00:39:14 Metformin
00:46:02 NAD Boosters
00:50:33 Increasing Blood Flow
00:53:20 Sleep
00:58:02 Overall Message: Keep your Brain Healthy
00:58:50 Next Week’s Episode and the Future of Medicine
01:01:21 Options for Subscription for Support
